Ontology highlight
ABSTRACT:
SUBMITTER: Drage MG
PROVIDER: S-EPMC2933325 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20100808 9
Knockout of lprG results in decreased virulence of Mycobacterium tuberculosis (MTB) in mice. MTB lipoprotein LprG has TLR2 agonist activity, which is thought to be dependent on its N-terminal triacylation. Unexpectedly, here we find that nonacylated LprG retains TLR2 activity. Moreover, we show LprG association with triacylated glycolipid TLR2 agonists lipoarabinomannan, lipomannan and phosphatidylinositol mannosides (which share core structures). Binding of triacylated species was specific to L ...[more]