Ontology highlight
ABSTRACT:
SUBMITTER: An P
PROVIDER: S-EPMC4215072 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
An Ping P Goedert James J JJ Donfield Sharyne S Buchbinder Susan S Kirk Gregory D GD Detels Roger R Winkler Cheryl A CA
The Journal of infectious diseases 20140519 10
<h4>Background</h4>ZNRD1 was identified as a host protein required for the completion of the human immunodeficiency virus (HIV) lifecycle in a genome-wide screen using small interfering RNA gene silencing. Subsequently, a genome-wide association study (GWAS) of host determinants for HIV-1 disease identified an association of single nucleotide polymorphisms (SNPs) in the ZNRD1 region with CD4(+) T-cell depletion.<h4>Methods</h4>We investigated the effects of SNPs in the ZNRD1 region on human immu ...[more]