Ontology highlight
ABSTRACT:
SUBMITTER: Jamshidi M
PROVIDER: S-EPMC4159753 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Jamshidi Maral M Schmidt Marjanka K MK Dörk Thilo T Garcia-Closas Montserrat M Heikkinen Tuomas T Cornelissen Sten S van den Broek Alexandra J AJ Schürmann Peter P Meyer Andreas A Park-Simon Tjoung-Won TW Figueroa Jonine J Sherman Mark M Lissowska Jolanta J Keong Garrett Teoh Hor GT Irwanto Astrid A Laakso Marko M Hautaniemi Sampsa S Aittomäki Kristiina K Blomqvist Carl C Liu Jianjun J Nevanlinna Heli H
International journal of cancer 20121025 9
Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five single nucleotide polymorphisms (SNPs) in PRKAG2 (rs1029946, rs4726050, rs6464153, rs7789699) and PPP2R2B (rs10477313) for 10-year survival in breast cancer patients, interaction with T ...[more]