Ontology highlight
ABSTRACT: Unlabelled
Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits.Clinical trials registration
NCT 01543958.
SUBMITTER: Sandler NG
PROVIDER: S-EPMC4215074 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Sandler Netanya G NG Zhang Xinyan X Bosch Ronald J RJ Funderburg Nicholas T NT Choi Andrew I AI Robinson Janet K JK Fine Derek M DM Coombs Robert W RW Jacobson Jeffrey M JM Landay Alan L AL Douek Daniel C DC Tressler Randall R Read Sarah W SW Wilson Cara C CC Deeks Steven G SG Lederman Michael M MM Gandhi Rajesh T RT
The Journal of infectious diseases 20140526 10
<h4>Unlabelled</h4>Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial ...[more]