New insights about enzyme evolution from large scale studies of sequence and structure relationships.
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ABSTRACT:
SUBMITTER: Brown SD
PROVIDER: S-EPMC4215206 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
New insights about enzyme evolution from large scale studies of sequence and structure relationships.
Brown Shoshana D SD Babbitt Patricia C PC
The Journal of biological chemistry 20140910 44
Understanding how enzymes have evolved offers clues about their structure-function relationships and mechanisms. Here, we describe evolution of functionally diverse enzyme superfamilies, each representing a large set of sequences that evolved from a common ancestor and that retain conserved features of their structures and active sites. Using several examples, we describe the different structural strategies nature has used to evolve new reaction and substrate specificities in each unique superfa ...[more]
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