Blocking FSH action attenuates osteoclastogenesis.
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ABSTRACT:
SUBMITTER: Zhu LL
PROVIDER: S-EPMC4219240 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Blocking FSH action attenuates osteoclastogenesis.
Zhu Ling-Ling LL Tourkova Irina I Yuen Tony T Robinson Lisa J LJ Bian Zhuan Z Zaidi Mone M Blair Harry C HC
Biochemical and biophysical research communications 20120427 1
A direct effect of FSH on bone turnover via stimulation of osteoclast formation has been reported. Here we show that monoclonal or polyclonal antibodies to FSH inhibit osteoclast formation induced by FSH to an extent similar to that noted in FSH receptor (FSHR) knockout cells. Furthermore, we document the amplification of FSHR cDNA from well-characterized human CD14+ osteoclast precursors and osteoclasts, and the direct sequencing of the PCR products to definitively establish the expression of F ...[more]
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