Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4220159 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Yang Yunfan Y Ran Jie J Liu Min M Li Dengwen D Li Yuanyuan Y Shi Xingjuan X Meng Dan D Pan Junmin J Ou Guangshuo G Aneja Ritu R Sun Shao-Cong SC Zhou Jun J
Cell research 20141024 11
Cilia are hair-like organelles extending from the cell surface with important sensory and motility functions. Ciliary defects can result in a wide range of human diseases known as ciliopathies. However, the molecular mechanisms controlling ciliogenesis remain poorly defined. Here we show that cylindromatosis (CYLD), a tumor suppressor protein harboring deubiquitinase activity, plays a critical role in the assembly of both primary and motile cilia in multiple organs. CYLD knockout mice exhibit po ...[more]