Ontology highlight
ABSTRACT:
SUBMITTER: Samara NL
PROVIDER: S-EPMC4220450 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Samara Nadine L NL Datta Ajit B AB Berndsen Christopher E CE Zhang Xiangbin X Yao Tingting T Cohen Robert E RE Wolberger Cynthia C
Science (New York, N.Y.) 20100415 5981
SAGA is a transcriptional coactivator complex that is conserved across eukaryotes and performs multiple functions during transcriptional activation and elongation. One role is deubiquitination of histone H2B, and this activity resides in a distinct subcomplex called the deubiquitinating module (DUBm), which contains the ubiquitin-specific protease Ubp8, bound to Sgf11, Sus1, and Sgf73. The deubiquitinating activity depends on the presence of all four DUBm proteins. We report here the 1.90 angstr ...[more]