Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC4380536 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yan Ming M Wolberger Cynthia C
Journal of molecular biology 20141217 8
The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex performs multiple functions in transcription activation including deubiquitinating histone H2B, which is mediated by a subcomplex called the deubiquitinating module (DUBm). The yeast DUBm comprises a catalytic subunit, Ubp8, and three additional subunits, Sgf11, Sus1 and Sgf73, all of which are required for DUBm activity. A portion of the non-globular Sgf73 subunit lies between the Ubp8 catalytic domain and the ZnF-UBP domain and has been propose ...[more]