Ontology highlight
ABSTRACT:
SUBMITTER: Chen JT
PROVIDER: S-EPMC4220496 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Chen Jeremy Tsung-chieh JT Guo Da D Campanelli Dario D Frattini Flavia F Mayer Florian F Zhou Luming L Kuner Rohini R Heppenstall Paul A PA Knipper Marlies M Hu Jing J
Nature communications 20141030
The gate control theory proposes the importance of both pre- and post-synaptic inhibition in processing pain signal in the spinal cord. However, although postsynaptic disinhibition caused by brain-derived neurotrophic factor (BDNF) has been proved as a crucial mechanism underlying neuropathic pain, the function of presynaptic inhibition in acute and neuropathic pain remains elusive. Here we show that a transient shift in the reversal potential (EGABA) together with a decline in the conductance o ...[more]