Mining tertiary structural motifs for assessment of designability.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4222026 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Mining tertiary structural motifs for assessment of designability.
Zhang Jian J Grigoryan Gevorg G
Methods in enzymology 20130101
The observation of a limited secondary-structural alphabet in native proteins, with significant sequence preferences, has profoundly influenced the fields of protein design and structure prediction (Simons, Kooperberg, Huang, & Baker, 1997; Verschueren et al., 2011). In the era of structural genomics, as the size of the structural dataset continues to grow rapidly, it is becoming possible to extend this analysis to tertiary structural motifs and their sequences. For a hypothetical tertiary motif ...[more]
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