Ontology highlight
ABSTRACT:
SUBMITTER: He F
PROVIDER: S-EPMC4222251 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
He Fei F Ge Weihong W Martinowich Keri K Becker-Catania Sara S Coskun Volkan V Zhu Wenyu W Wu Hao H Castro Diogo D Guillemot Francois F Fan Guoping G de Vellis Jean J Sun Yi E YE
Nature neuroscience 20050424 5
During development of the CNS, neurons and glia are generated in a sequential manner. The mechanism underlying the later onset of gliogenesis is poorly understood, although the cytokine-induced Jak-STAT pathway has been postulated to regulate astrogliogenesis. Here, we report that the overall activity of Jak-STAT signaling is dynamically regulated in mouse cortical germinal zone during development. As such, activated STAT1/3 and STAT-mediated transcription are negligible at early, neurogenic sta ...[more]