Signal, transduction, and the hematopoietic stem cell.
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ABSTRACT:
SUBMITTER: Louria-Hayon I
PROVIDER: S-EPMC4222422 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Signal, transduction, and the hematopoietic stem cell.
Rambam Maimonides medical journal 20141029 4
The hematopoietic stem cell (HSC) is a unique cell positioned highest in the hematopoietic hierarchical system. The HSC has the ability to stay in quiescence, to self-renew, or to differentiate and generate all lineages of blood cells. The path to be actualized is influenced by signals that derive from the cell's microenvironment, which activate molecular pathways inside the cell. Signaling pathways are commonly organized through inducible protein-protein interactions, mediated by adaptor protei ...[more]
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