Ontology highlight
ABSTRACT:
SUBMITTER: Applebaum MA
PROVIDER: S-EPMC4222525 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Applebaum Mark A MA Skol Andrew D AD Bond Elisabeth E EE Overholtzer Michael M Bond Gareth L GL Onel Kenan K
International journal of radiation biology 20140625 10
<h4>Purpose</h4>Although there are considerable data on mechanisms of radiation-induced apoptosis in vitro and in animal models, little is known about functional variation in these pathways in humans. We sought to develop a tractable system to evaluate this.<h4>Materials and methods</h4>Peripheral blood mononuclear cells were isolated from 90 healthy volunteers, divided into two aliquots, one irradiated with a 5 Gy dose and the other sham-treated (0 Gy), and assessed for damage-induced apoptosis ...[more]