Ontology highlight
ABSTRACT:
SUBMITTER: Castro A
PROVIDER: S-EPMC7431859 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200817 1
Individual MHC genotype constrains the mutational landscape during tumorigenesis. Immune checkpoint inhibition reactivates immunity against tumors that escaped immune surveillance in approximately 30% of cases. Recent studies demonstrated poorer response rates in female and younger patients. Although immune responses differ with sex and age, the role of MHC-based immune selection in this context is unknown. We find that tumors in younger and female individuals accumulate more poorly presented dr ...[more]