Ontology highlight
ABSTRACT:
SUBMITTER: Sjolund A
PROVIDER: S-EPMC4222680 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Sjolund Ashley A Nemec Antonia A AA Paquet Nicolas N Prakash Aishwarya A Sung Patrick P Doublié Sylvie S Sweasy Joann B JB
PLoS genetics 20141106 11
Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU) paired with adenine or guanine. The rs4135113 single nucleotide polymorphism (SNP) of TDG is found in 10% of the global population. This coding SNP results in the alteration of Gly199 to Ser. Gly199 i ...[more]