Ontology highlight
ABSTRACT:
SUBMITTER: Pritchard JR
PROVIDER: S-EPMC4222735 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Pritchard Justin R JR Chao Michael C MC Chao Michael C MC Abel Sören S Davis Brigid M BM Baranowski Catherine C Zhang Yanjia J YJ Rubin Eric J EJ Waldor Matthew K MK
PLoS genetics 20141106 11
Transposon-insertion sequencing (TIS) is a powerful approach for deciphering genetic requirements for bacterial growth in different conditions, as it enables simultaneous genome-wide analysis of the fitness of thousands of mutants. However, current methods for comparative analysis of TIS data do not adjust for stochastic experimental variation between datasets and are limited to interrogation of annotated genomic elements. Here, we present ARTIST, an accessible TIS analysis pipeline for identify ...[more]