Ontology highlight
ABSTRACT:
SUBMITTER: Brier MR
PROVIDER: S-EPMC4223085 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Brier Matthew R MR Thomas Jewell B JB Snyder Abraham Z AZ Wang Liang L Fagan Anne M AM Benzinger Tammie T Morris John C JC Ances Beau M BM
Neurology 20140926 18
<h4>Objective</h4>To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone.<h4>Methods</h4>We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We investigated 2 groups of cognitively normal participants: one group with evidence of preclinical AD as assessed by CSF markers of AD and the other group with normal C ...[more]