Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez F
PROVIDER: S-EPMC4223295 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Rodriguez Fernanda F Lillington James J Johnson Steven S Timmel Christiane R CR Lea Susan M SM Berks Ben C BC
The Journal of biological chemistry 20140912 45
The PhoD family of extra-cytoplasmic phosphodiesterases are among the most commonly occurring bacterial phosphatases. The exemplars for this family are the PhoD protein of Bacillus subtilis and the phospholipase D of Streptomyces chromofuscus. We present the crystal structure of B. subtilis PhoD. PhoD is most closely related to purple acid phosphatases (PAPs) with both types of enzyme containing a tyrosinate-ligated Fe(3+) ion. However, the PhoD active site diverges from that found in PAPs and u ...[more]