Ontology highlight
ABSTRACT:
SUBMITTER: Kremneva E
PROVIDER: S-EPMC4223631 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Developmental cell 20141001 2
ADF/cofilins drive cytoskeletal dynamics by promoting the disassembly of "aged" ADP-actin filaments. Mammals express several ADF/cofilin isoforms, but their specific biochemical activities and cellular functions have not been studied in detail. Here, we demonstrate that the muscle-specific isoform cofilin-2 promotes actin filament disassembly in sarcomeres to control the precise length of thin filaments in the contractile apparatus. In contrast to other isoforms, cofilin-2 efficiently binds and ...[more]