Ontology highlight
ABSTRACT:
SUBMITTER: Morselli E
PROVIDER: S-EPMC4223650 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Morselli Eugenia E Fuente-Martin Esther E Finan Brian B Kim Min M Frank Aaron A Garcia-Caceres Cristina C Navas Carlos Rodriguez CR Gordillo Ruth R Neinast Michael M Kalainayakan Sarada P SP Li Dan L DL Gao Yuanqing Y Yi Chun-Xia CX Hahner Lisa L Palmer Biff F BF Tschöp Matthias H MH Clegg Deborah J DJ
Cell reports 20141016 2
High-fat diets (HFDs) lead to obesity and inflammation in the central nervous system (CNS). Estrogens and estrogen receptor α (ERα) protect premenopausal females from the metabolic complications of inflammation and obesity-related disease. Here, we demonstrate that hypothalamic PGC-1α regulates ERα and inflammation in vivo. HFD significantly increased palmitic acid (PA) and sphingolipids in the CNS of male mice when compared to female mice. PA, in vitro, and HFD, in vivo, reduced PGC-1α and ERα ...[more]