Ontology highlight
ABSTRACT:
SUBMITTER: Aleman A
PROVIDER: S-EPMC4223678 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20141107
The BMP ligand Dpp, operates as a long range morphogen to control many important functions during Drosophila development from tissue patterning to growth. The BMP signal is transduced intracellularly via C-terminal phosphorylation of the BMP transcription factor Mad, which forms an activity gradient in developing embryonic tissues. Here we show that Cyclin dependent kinase 8 and Shaggy phosphorylate three Mad linker serines. We demonstrate that linker phosphorylations control the peak intensity ...[more]