Ontology highlight
ABSTRACT:
SUBMITTER: Serpe M
PROVIDER: S-EPMC2488203 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Serpe Mihaela M Umulis David D Ralston Amy A Chen Jun J Olson David J DJ Avanesov Andrei A Othmer Hans H O'Connor Michael B MB Blair Seth S SS
Developmental cell 20080601 6
In Drosophila, the secreted BMP-binding protein Short gastrulation (Sog) inhibits signaling by sequestering BMPs from receptors, but enhances signaling by transporting BMPs through tissues. We show that Crossveinless 2 (Cv-2) is also a secreted BMP-binding protein that enhances or inhibits BMP signaling. Unlike Sog, however, Cv-2 does not promote signaling by transporting BMPs. Rather, Cv-2 binds cell surfaces and heparan sulfate proteoglygans and acts over a short range. Cv-2 binds the type I B ...[more]