Ontology highlight
ABSTRACT:
SUBMITTER: Thoma EC
PROVIDER: S-EPMC4223700 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Thoma Eva C EC Merkl Claudia C Heckel Tobias T Haab Rachel R Knoflach Frederic F Nowaczyk Corinne C Flint Nicholas N Jagasia Ravi R Jensen Zoffmann Sannah S Truong Hoa Hue HH Petitjean Pascal P Jessberger Sebastian S Graf Martin M Iacone Roberto R
Stem cell reports 20140911 4
Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects. Here, we present a gene-free approach that allows efficient conversion of human fibroblasts via a transient progenitor stage into Schwann cells, the major glial cell type of peripheral nerves. Using a multikinase inhibitor, we transdifferentiated fibrob ...[more]