Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4224420 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chen Li L Choyke Peter L PL Wang Niya N Clarke Robert R Bhujwalla Zaver M ZM Hillman Elizabeth M C EM Wang Ge G Wang Yue Y
PloS one 20141107 11
With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartment modeling (MTCM), a completely unsupervised method of deconvoluting dynamic imaging series from heter ...[more]