Ontology highlight
ABSTRACT:
SUBMITTER: Agollah GD
PROVIDER: S-EPMC4226566 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Agollah Germaine D GD Gonzalez-Garay Manuel L ML Rasmussen John C JC Tan I-Chih IC Aldrich Melissa B MB Darne Chinmay C Fife Caroline E CE Guilliod Renie R Maus Erik A EA King Philip D PD Sevick-Muraca Eva M EM
PloS one 20141110 11
The lymphatic vasculature plays a critical role in a number of disease conditions of increasing prevalence, such as autoimmune disorders, obesity, blood vascular diseases, and cancer metastases. Yet, unlike the blood vasculature, the tools available to interrogate the molecular basis of lymphatic dysfunction/disease have been lacking. More recently, investigators have reported that dysregulation of the PI3K pathway is involved in syndromic human diseases that involve abnormal lymphatic vasculatu ...[more]