SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.
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ABSTRACT:
SUBMITTER: Fessler SP
PROVIDER: S-EPMC3165847 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Publications
SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.
Fessler Shawn P SP Rosenberg Naomi N Baughn Linda B LB
Journal of virology 20110622 17
v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. Consistent with this, we show that v-Abl expression reduces levels of full-length p145 SHIP in a v-Abl kinase activity-dependent fashion. This event requires signals from ...[more]
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