Ontology highlight
ABSTRACT:
SUBMITTER: Ye R
PROVIDER: S-EPMC4228265 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Ye Risheng R Holland William L WL Gordillo Ruth R Wang Miao M Wang Qiong A QA Shao Mengle M Morley Thomas S TS Gupta Rana K RK Stahl Andreas A Scherer Philipp E PE
eLife 20141023
As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role under regular chow. Employing a mouse model with inducible, acute β-cell ablation, we uncovered an essential role of adiponectin under insulinopenic conditions to maintain minimal lipid homeostasis. When insulin levels are marginal, adiponectin is c ...[more]