Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4746598 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Liu Ying Y Takahashi Yoshinori Y Desai Neelam N Zhang Jun J Serfass Jacob M JM Shi Yu-Guang YG Lynch Christopher J CJ Wang Hong-Gang HG
Scientific reports 20160209
Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development of obesity and insulin resistance upon aging or dietary challenge. Our data show that Bif-1 deficiency promotes the expansion of adipose tissue mass without altering food intake or physical activities. While Bif-1 is dispensable for adipo ...[more]