Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer.
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ABSTRACT: Aim
To analyze the serum nicotinamide phosphoribosyltransferase (Nampt) level and its prognostic value in bladder cancer (BC).Methods
The study included 131 patients with transitional cell BC and 109 healthy controls from the West China Hospital of Sichuan University in the period between 2007 and 2013. Nampt concentration in serum was measured by commercial ELISA kits for human Nampt.Results
The serum Nampt protein level in patients with BC (mean ± standard deviation, 16.02 ± 7.95 ng/mL) was significantly higher than in the control group (6.46 ± 2.08 ng/mL) (P < 0.001). Serum Nampt level was an independent prognostic marker of non-muscle-invasive BC, with a higher serum Nampt level (>14.74 ng/mL) indicating shorter recurrence-free survival rate (hazard ratio=2.85, 95% confidence interval, 1.01-8.06; P=0.048).Conclusion
Our results suggest that serum Nampt level may serve as a biomarker of BC and an independent prognostic marker of non-muscle-invasive BC.
SUBMITTER: Zhang K
PROVIDER: S-EPMC4228298 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer.
Zhang Kui K Zhou Bin B Zhang Peng P Zhang Zhu Z Chen Peng P Pu Yan Y Song Yaping Y Zhang Lin L
Croatian medical journal 20141001 5
<h4>Aim</h4>To analyze the serum nicotinamide phosphoribosyltransferase (Nampt) level and its prognostic value in bladder cancer (BC).<h4>Methods</h4>The study included 131 patients with transitional cell BC and 109 healthy controls from the West China Hospital of Sichuan University in the period between 2007 and 2013. Nampt concentration in serum was measured by commercial ELISA kits for human Nampt.<h4>Results</h4>The serum Nampt protein level in patients with BC (mean ± standard deviation, 16 ...[more]
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