Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC4228696 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Yang Liu L Miao Linqing L Liang Feisi F Huang Haoliang H Teng Xiuyin X Li Shaohua S Nuriddinov Jaloliddin J Selzer Michael E ME Hu Yang Y
Nature communications 20141110
Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that activation of the mammalian target of rapamycin complex 1 (mTORC1) in mature retinal ganglion cells by deletion of the negative regulators, phosphatase and tensin homologue (PTEN), and tuberous sclerosis 1 promotes ON regeneration. mTORC1 activation inhibits eukaryotic translation initiation factor 4E-binding protein (4E-BP) and activates ribosomal protein S6 kinase 1 (S6K1), both of which stimulate translati ...[more]