Ontology highlight
ABSTRACT:
SUBMITTER: Pinto-Costa R
PROVIDER: S-EPMC7108904 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pinto-Costa Rita R Sousa Sara C SC Leite Sérgio C SC Nogueira-Rodrigues Joana J Ferreira da Silva Tiago T Machado Diana D Marques Joana J Costa Ana Catarina AC Liz Márcia A MA Bartolini Francesca F Brites Pedro P Costell Mercedes M Fässler Reinhard R Sousa Mónica M MM
The Journal of clinical investigation 20200401 4
After trauma, regeneration of adult CNS axons is abortive, causing devastating neurologic deficits. Despite progress in rehabilitative care, there is no effective treatment that stimulates axonal growth following injury. Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin 1 (Pfn1) as a coordinator of actin and microtubules (MTs), powering axonal growth and regeneration. In growth cones, Pfn1 increased actin retrograde flow, ...[more]