Ontology highlight
ABSTRACT:
SUBMITTER: Kohsaka A
PROVIDER: S-EPMC4229239 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kohsaka Akira A Das Partha P Hashimoto Izumi I Nakao Tomomi T Deguchi Yoko Y Gouraud Sabine S SS Waki Hidefumi H Muragaki Yasuteru Y Maeda Masanobu M
PloS one 20141112 11
Cardiac function is highly dependent on oxidative energy, which is produced by mitochondrial respiration. Defects in mitochondrial function are associated with both structural and functional abnormalities in the heart. Here, we show that heart-specific ablation of the circadian clock gene Bmal1 results in cardiac mitochondrial defects that include morphological changes and functional abnormalities, such as reduced enzymatic activities within the respiratory complex. Mice without cardiac Bmal1 fu ...[more]