Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5543814 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Liu Xiao X Dang Yunkun Y Matsu-Ura Toru T He Yubo Y He Qun Q Hong Christian I CI Liu Yi Y
Molecular cell 20170622 2
Although the coupling between circadian and cell cycles allows circadian clocks to gate cell division and DNA replication in many organisms, circadian clocks were thought to function independently of cell cycle. Here, we show that DNA replication is required for circadian clock function in Neurospora. Genetic and pharmacological inhibition of DNA replication abolished both overt and molecular rhythmicities by repressing frequency (frq) gene transcription. DNA replication is essential for the rhy ...[more]