Dataset Information
Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway.
Ontology highlight
ABSTRACT: Background
Angelica Sinensis (AS), a folk medicine, has long been used in ergogenic aids for athletes, but there is little scientific evidence supporting its effects. We investigated whether AS induces hypertrophy in myotubes through the phosphatidylinositol 3-kinase (PI3K)/Akt (also termed PKB)/mammalian target of the rapamycin (mTOR) pathway.Methods
An in vitro experiment investigating the induction of hypertrophy in myotubes was conducted. To investigate whether AS promoted the hypertrophy of myotubes, an established in vitro model of myotube hypertrophy with and without AS was used and examined using microscopic images. The role of the PI3K/Akt/mTOR signaling pathway in AS-induced myotube hypertrophy was evaluated. Two inhibitors, wortmannin (an inhibitor of PI3K) and rapamycin (an inhibitor of mTOR), were used.Result
The results revealed that the myotube diameters in the AS-treated group were significantly larger than those in the untreated control group (P?ConclusionThe results confirmed that AS induces hypertrophy in myotubes through the PI3K/Akt/mTOR pathway.
SUBMITTER: Yeh TS
PROVIDER: S-EPMC4229743 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway.
BMC complementary and alternative medicine 20140503
<h4>Background</h4>Angelica Sinensis (AS), a folk medicine, has long been used in ergogenic aids for athletes, but there is little scientific evidence supporting its effects. We investigated whether AS induces hypertrophy in myotubes through the phosphatidylinositol 3-kinase (PI3K)/Akt (also termed PKB)/mammalian target of the rapamycin (mTOR) pathway.<h4>Methods</h4>An in vitro experiment investigating the induction of hypertrophy in myotubes was conducted. To investigate whether AS promoted th ...[more]
