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Identification of a transcriptional signature for the wound healing continuum.

ABSTRACT: There is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring within skin and the nonhealing of chronic skin wounds. Central to these outcomes is the role of the fibroblast. Global gene expression profiling utilizing microarrays is starting to give insight into the role of such cells during the healing process, but no studies to date have produced a gene signature for this wound healing continuum. Microarray analysis of adult oral mucosal fibroblast (OMF), normal skin fibroblast (NF), and chronic wound fibroblast (CWF) at 0 and 6 hours post-serum stimulation was performed. Genes whose expression increases following serum exposure in the order OMF?

SUBMITTER: Peake MA

PROVIDER: S-EPMC4230470 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature

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Identification of a transcriptional signature for the wound healing continuum.

Peake Matthew A MA Caley Mathew M Giles Peter J PJ Wall Ivan I Enoch Stuart S Davies Lindsay C LC Kipling David D Thomas David W DW Stephens Phil P

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20140501 3

There is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring within skin and the nonhealing of chronic skin wounds. Central to these outcomes is the role of the fibroblast. Global gene expression profiling utilizing microarrays is starting to give insight into the role of such cells during the healing process, but no studies to date have produced a gene signature for this wound healing continuum. Micro ...[more]

PMID: 24844339

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