Ontology highlight
ABSTRACT:
SUBMITTER: Arciero JC
PROVIDER: S-EPMC3030184 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Arciero Julia C JC Mi Qi Q Branca Maria F MF Hackam David J DJ Swigon David D
Biophysical journal 20110201 3
Collective cell migration plays an important role during wound healing and embryo development. Although the exact mechanisms that coordinate such migration are still unknown, experimental studies of moving cell layers have shown that the primary interactions governing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, and the adhesion of cells to each other. Here, we derive a two-dimensional continuum mechanical model of cell-layer migration that is ba ...[more]