Ontology highlight
ABSTRACT:
SUBMITTER: Foster WH
PROVIDER: S-EPMC4230483 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Foster William H WH Langenbacher Adam A Gao Chen C Chen Jaunian J Wang Yibin Y
Developmental dynamics : an official publication of the American Association of Anatomists 20130726 9
<h4>Background</h4>PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown.<h4>Results</h4>Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g(-/-) mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed i ...[more]