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Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

ABSTRACT: Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

SUBMITTER: Goetzl EJ

PROVIDER: S-EPMC4531059 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

Goetzl Edward J EJ Boxer Adam A Schwartz Janice B JB Abner Erin L EL Petersen Ronald C RC Miller Bruce L BL Carlson Olga D OD Mustapic Maja M Kapogiannis Dimitrios D

Annals of clinical and translational neurology 20150513 7

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant differ ...[more]

PMID: 26273689

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Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

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Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

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