Macrophage heterogeneity in tissues: phenotypic diversity and functions.
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ABSTRACT:
SUBMITTER: Gordon S
PROVIDER: S-EPMC4231239 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Macrophage heterogeneity in tissues: phenotypic diversity and functions.
Gordon Siamon S Plüddemann Annette A Martinez Estrada Fernando F
Immunological reviews 20141101 1
During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue-resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults. We have learned a great deal about macrophage properties ex vivo and in cell culture, but their phenotypic heterogeneity within different tissue microenvironments remains poorly ...[more]
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