Ontology highlight
ABSTRACT:
SUBMITTER: Vorup-Jensen T
PROVIDER: S-EPMC2040231 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20070712 9
Integrins are cell-surface heterodimeric proteins that mediate cell-cell, cell-matrix, and cell-pathogen interactions. Half of the known integrin alpha subunits contain inserted domains (I domains) that coordinate ligand through a metal ion. Although the importance of conformational changes within isolated I domains in regulating ligand binding has been reported, the relationship between metal ion binding affinity and ligand binding affinity has not been elucidated. Metal and ligand binding by s ...[more]