Ontology highlight
ABSTRACT:
SUBMITTER: Joo JE
PROVIDER: S-EPMC4231404 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
European journal of human genetics : EJHG 20140409 12
The phenomenon of X chromosome inactivation in female mammals is well characterised and remains the archetypal example of dosage compensation via monoallelic expression. The temporal series of events that culminates in inactive X-specific gene silencing by DNA methylation has revealed a 'patchwork' of gene inactivation along the chromosome, with approximately 15% of genes escaping. Such genes are therefore potentially subject to sex-specific imbalance between males and females. Aside from XIST, ...[more]