Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.
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ABSTRACT:
SUBMITTER: Byun HM
PROVIDER: S-EPMC4481584 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.
Byun Hyang-Min HM Siegmund Kimberly D KD Pan Fei F Weisenberger Daniel J DJ Kanel Gary G Laird Peter W PW Yang Allen S AS
Human molecular genetics 20090923 24
DNA methylation is known to be associated with cell differentiation, aging, disease and cancer. There exists an expanding base of knowledge regarding tissue-specific DNA methylation, but we have little information about person-specific DNA methylation. Here, we analyze the DNA methylation patterns of multiple tissues from multiple individuals using a high-throughput quantitative assay of genome-wide DNA methylation, namely the Illumina GoldenGate BeadArray. DNA methylation patterns were largely ...[more]
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