Ontology highlight
ABSTRACT:
SUBMITTER: Leblanc R
PROVIDER: S-EPMC4231421 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Leblanc Raphael R Lee Sue-Chin SC David Marion M Bordet Jean-Claude JC Norman Derek D DD Patil Renukadevi R Miller Duane D Sahay Debashish D Ribeiro Johnny J Clézardin Philippe P Tigyi Gabor J GJ Peyruchaud Olivier O
Blood 20141002 20
Autotaxin (ATX), through its lysophospholipase D activity controls physiological levels of lysophosphatidic acid (LPA) in blood. ATX is overexpressed in multiple types of cancers, and together with LPA generated during platelet activation promotes skeletal metastasis of breast cancer. However, the pathophysiological sequelae of regulated interactions between circulating LPA, ATX, and platelets remain undefined in cancer. In this study, we show that ATX is stored in α-granules of resting human pl ...[more]