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Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.

ABSTRACT: The molecular genetic basis of electrodermal activity (EDA) was analyzed using 527,829 single nucleotide polymorphisms (SNPs) in a large population-representative sample of twins and parents (N?=?4,424) in relation to various EDA indices. Biometric analyses suggested that approximately 50% or more of variance in all EDA indices was heritable. The combined effect of all SNPs together accounted for a significant amount of variance in each index, affirming their polygenic basis and heritability. However, none of the SNPs were genome-wide significant for any EDA index. Previously reported SNP associations with disorders such as substance dependence or schizophrenia, which have been linked to EDA abnormalities, were not significant; nor were associations between EDA and genes in specific neurotransmitter systems. These results suggest that EDA is influenced by multiple genes rather than by polymorphisms with large effects.

SUBMITTER: Vaidyanathan U

PROVIDER: S-EPMC4231605 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.

Vaidyanathan Uma U Isen Joshua D JD Malone Stephen M SM Miller Michael B MB McGue Matt M Iacono William G WG

Psychophysiology 20141201 12

The molecular genetic basis of electrodermal activity (EDA) was analyzed using 527,829 single nucleotide polymorphisms (SNPs) in a large population-representative sample of twins and parents (N = 4,424) in relation to various EDA indices. Biometric analyses suggested that approximately 50% or more of variance in all EDA indices was heritable. The combined effect of all SNPs together accounted for a significant amount of variance in each index, affirming their polygenic basis and heritability. Ho ...[more]

PMID: 25387706

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Dataset Information

Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.

Publications

Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.

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