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Piezo proteins: regulators of mechanosensation and other cellular processes.

ABSTRACT: Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.

SUBMITTER: Bagriantsev SN

PROVIDER: S-EPMC4231648 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Piezo proteins: regulators of mechanosensation and other cellular processes.

Bagriantsev Sviatoslav N SN Gracheva Elena O EO Gallagher Patrick G PG

The Journal of biological chemistry 20141010 46

Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular develop ...[more]

PMID: 25305018

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