Ontology highlight
ABSTRACT:
SUBMITTER: Shyer AE
PROVIDER: S-EPMC5605277 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170713 6353
The spacing of hair in mammals and feathers in birds is one of the most apparent morphological features of the skin. This pattern arises when uniform fields of progenitor cells diversify their molecular fate while adopting higher-order structure. Using the nascent skin of the developing chicken embryo as a model system, we find that morphological and molecular symmetries are simultaneously broken by an emergent process of cellular self-organization. The key initiators of heterogeneity are dermal ...[more]