Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi K
PROVIDER: S-EPMC4231759 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kobayashi Kan K Katz Assaf A Rajkovic Andrei A Ishii Ryohei R Branson Owen E OE Freitas Michael A MA Ishitani Ryuichiro R Ibba Michael M Nureki Osamu O
Nucleic acids research 20141001 19
EF-P is a bacterial tRNA-mimic protein, which accelerates the ribosome-catalyzed polymerization of poly-prolines. In Escherichia coli, EF-P is post-translationally modified on a conserved lysine residue. The post-translational modification is performed in a two-step reaction involving the addition of a β-lysine moiety and the subsequent hydroxylation, catalyzed by PoxA and YfcM, respectively. The β-lysine moiety was previously shown to enhance the rate of poly-proline synthesis, but the role of ...[more]