Unknown

Dataset Information

0

Metal coordination-directed hydroxylation of steroids with a novel artificial P-450 catalyst.


ABSTRACT: [structure: see text] A novel catalyst has been synthesized in which a manganese-porphyrin unit is linked to two 2,2'-bipyridyl groups and two pentafluorophenyl groups in trans fashion on its four meso positions. Relative to a previous catalyst in which the manganese-porphyrin had four 2,2'-bipyridyl groups, the new catalyst, in the presence of Cu(2+) ions as coordinating linkers, catalyzes the oxidation of a steroid substrate with much better regioselectivity and higher turnover numbers.

SUBMITTER: Fang Z 

PROVIDER: S-EPMC2533127 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Metal coordination-directed hydroxylation of steroids with a novel artificial P-450 catalyst.

Fang Zhenglai Z   Breslow Ronald R  

Organic letters 20060101 2


[structure: see text] A novel catalyst has been synthesized in which a manganese-porphyrin unit is linked to two 2,2'-bipyridyl groups and two pentafluorophenyl groups in trans fashion on its four meso positions. Relative to a previous catalyst in which the manganese-porphyrin had four 2,2'-bipyridyl groups, the new catalyst, in the presence of Cu(2+) ions as coordinating linkers, catalyzes the oxidation of a steroid substrate with much better regioselectivity and higher turnover numbers. ...[more]

Similar Datasets

| S-EPMC1131727 | biostudies-other
| S-EPMC11005052 | biostudies-literature
| S-EPMC7449529 | biostudies-literature
| S-EPMC6662754 | biostudies-literature
| S-EPMC1150019 | biostudies-other
| S-EPMC4231759 | biostudies-literature
| S-EPMC3138472 | biostudies-literature
| S-EPMC7067857 | biostudies-literature
| S-EPMC1151109 | biostudies-other
| S-EPMC8565389 | biostudies-literature