Ontology highlight
ABSTRACT:
SUBMITTER: Bijker EM
PROVIDER: S-EPMC4232459 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bijker Else M EM Schats Remko R Obiero Joshua M JM Behet Marije C MC van Gemert Geert-Jan GJ van de Vegte-Bolmer Marga M Graumans Wouter W van Lieshout Lisette L Bastiaens Guido J H GJ Teelen Karina K Hermsen Cornelus C CC Scholzen Anja A Visser Leo G LG Sauerwein Robert W RW
PloS one 20141114 11
Immunization of healthy volunteers with chloroquine ChemoProphylaxis and Sporozoites (CPS-CQ) efficiently and reproducibly induces dose-dependent and long-lasting protection against homologous Plasmodium falciparum challenge. Here, we studied whether chloroquine can be replaced by mefloquine, which is the only other licensed anti-malarial chemoprophylactic drug that does not affect pre-erythrocytic stages, exposure to which is considered essential for induction of protection by CPS immunization. ...[more]